P M van der Kraan Selected Research

Osteophyte

1/2019	Exploring longitudinal associations of histologically assessed inflammation with symptoms and radiographic damage in knee osteoarthritis: combined results of three prospective cohort studies.
1/2016	Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.
12/2015	Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.
6/2015	Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage.
12/2007	Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation.
6/2007	TGF-beta and osteoarthritis.
11/2006	Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation.
10/2001	Growth factors and cartilage repair.
2/2001	Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation.

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P M van der Kraan Research Topics

Disease

24	Osteoarthritis 10/2021 - 01/2000
9	Osteophyte 01/2019 - 02/2001
7	Fibrosis (Cirrhosis) 01/2022 - 05/2005
4	Synovitis 12/2018 - 12/2015
3	Pain (Aches) 01/2019 - 03/2015
2	Arthritis (Polyarthritis) 01/2020 - 03/2000
2	Inflammation (Inflammations) 01/2017 - 05/2016
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020
1	Bone Resorption 01/2020
1	Joint Diseases (Joint Disease) 01/2017
1	Necrosis 12/2015
1	Arthralgia (Joint Pain) 05/2008
1	Rheumatic Diseases (Rheumatism) 05/2005
1	Rheumatoid Arthritis 02/2001
1	Hyperplasia 02/2001

Drug/Important Bio-Agent (IBA)

10	Transforming Growth Factor beta (TGF-beta)IBA 01/2013 - 01/2000
7	Collagenases (Collagenase)FDA Link 10/2021 - 11/2006
3	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2017
3	CytokinesIBA 10/2021 - 12/2002
3	oxidized low density lipoproteinIBA 01/2020 - 05/2016
2	CollagenIBA 01/2022 - 03/2014
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2021 - 03/2014
2	Apolipoproteins E (ApoE)IBA 01/2020 - 05/2016
2	Proteoglycans (Proteoglycan)IBA 01/2019 - 05/2006
2	Nerve Growth Factor (NGF)IBA 01/2017 - 03/2015
2	Interleukin-1 (Interleukin 1)IBA 01/2017 - 05/2005
2	AlarminsIBA 01/2016 - 12/2015
2	Matrix Metalloproteinases (MMPs)IBA 01/2016 - 12/2015
2	Bone Morphogenetic Protein 2IBA 06/2015 - 12/2007
2	Collagen Type II (Type II Collagen)IBA 05/2001 - 09/2000
1	ErbB Receptors (EGF Receptor)IBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	LuciferasesIBA 01/2022
1	AntibodiesIBA 10/2021
1	Blocking AntibodiesIBA 10/2021
1	AntigensIBA 01/2020
1	FibrinIBA 01/2019
1	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2018
1	lubricinIBA 01/2017
1	RNA (Ribonucleic Acid)IBA 01/2017
1	CholesterolIBA 05/2016
1	Cartilage Oligomeric Matrix ProteinIBA 01/2016
1	peptide VDIPENIBA 01/2016
1	C-Reactive ProteinIBA 01/2016
1	paquinimodIBA 12/2015
1	InterleukinsIBA 12/2015
1	safranine T (safranin)IBA 06/2015
1	2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine (Lysyl Hydroxylase)IBA 01/2013
1	pyridinolineIBA 01/2013
1	SKI 306XIBA 05/2008
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 12/2007
1	Procollagen Type IIBA 05/2006
1	Connective Tissue Growth FactorIBA 05/2006
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2001
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 02/2001
1	Collagen Type XIBA 02/2001
1	ZymosanIBA 03/2000

Therapy/Procedure

2	Injections 01/2017 - 01/2000
1	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2019
1	Therapeutics 01/2017
1	Intra-Articular Injections 01/2000